Bioprinting

Polish Fundacja sets goal of bioprinting functional bionic pancreas by 2022

CELLINK bioprinter is key to implementation of islets of Langerhans bioink

According to WHO’s statistics, the number of diabetic patients (200,000 of which are patients with type I diabetes) will double by 2030. Chronic insulin therapy with constantly improved insulin pumps and systems for continuous glycemic measurement is a viable combination for a large number of patients. For the present, the only way to achieve a complete cure is to transplant the pancreas or, to a lesser extent, transplantation of islets of Langerhans. However, these methods are difficult and present numerous drawbacks, such as the shortage of organs for transplantation, chronic immunosuppression or the risk of surgical complications after pancreas transplantation. To meet the difficulties posed by the current concept of combating illness, a new idea emerged at Polish association Fundacja Badan Rozwoju Nauki (Foundation for Research and Science Development): the idea of creating a bionic pancreas.

Three years timeline

bionic pancreasIf the program succeeds, in 3 years time scientists will be prepared to carry out first trials with the participation of human patients. “We can see that many diabetics look at our work with hope, giving us strength and willingness to act,” said Michał Wszoła MD, PhD who is leading the project. “I would like to point out that this type of research is unique on a global scale. Moreover, Polish Bionic Consortium is among the leaders of centers dealing with this subject.”

Dr. Wszola states that the only path leading to a complete cure is pancreas or islets of Langerhans transplantation. This method of treating diabetes does not eliminate all problems. In Poland, about 10.000 people should be qualified for this type of transplant, whereas only 40 operations are performed annually on average. The main limitation affecting these frightening data is the shortage of organs for transplantation.

It is commonly known that although every year the state of knowledge of Poles improves, and the number of transplants is growing, the demand for organs exceeds the amount that can be obtained from donors. In addition, after pancreas transplantation, the operation itself carries the risk of surgical complications, and the continuation of life after both islets of Langerhans and pancreas transplantation is associated with the continuous intake of immunosuppressive drugs. The pancreas created from its own transformed stem cells eliminates these two major problems.

The group of Polish scientists led by Wszoła attempted to find a more effective way to help the ever-growing number of people affected by diabetes. This built into a unique project on a global scale with the ultimate goal of producing a bionic pancreas.

The BIONIC consortium

In October 2015 of Foundation’s of Research and Science Development initiative, the BIONIC consortium was established and it consists of:

  • The Foundation of Research and Science Development together with a team of Michal Wszola MD, PhD as a consortium leader.
  • The Nencki Institute of Experimental Biology together with a team of prof. Agnieszka Dobrzyn.
  • The faculty of Material Science of the Warsaw University of Technology under the directorship of prof. Wojciech Swieszkowski.
  • The Center for Biostructure Research of Warsaw Medical University under the directorship of prof. Artur Kaminski
  • The Jesus Child Hospital together with prof. Artur Kwiatkowski

The consortium implements the project titled “3D bioprinting of scaffolds using pancreatic islets or insulin-producing cells in order to create bionic pancreas”. After receiving funding from the National Center for Research and Development in January 2017 under the STRATEGMED III program, the work on the bionic pancreas started in full swing.

The ultimate goal of the project is to create a functional pancreas. One that can be transplanted to the patient without major problems. It will enable people affected by diabetes to function normally, and more importantly prevent the development of secondary complications, which are the causes of most deaths.

A bionic pancreas for implantation

A bionic pancreas is an organ made of biological elements, including cells from the patient, which eliminates the need for immunosuppression. Stem cells collected from the patient are subsequently placed into a complete organ using engineering and mechatronics. The innovation of the project is based on the use of the latest technologies – including CELLINK‘s Bio X bioprinter – and pioneering research on the human body, resulting in the unique composition of the bioink.

bionic pancreas

“Our ‘pancreas’, in contrast to the bony bioprint that is nowadays coming into the clinic, is to include not only scaffolding elements but also living cells and pancreatic islets along with the vascular system,” Dr. Wszoła explains. “It will ensure maintenance and enable their proper functioning in this environment. Another advantage of this innovative project is that after transplanting previously isolated stem cells from adipose tissue, and programming them so that they are able to secrete insulin and glucagon, they will become a completely new type of cells. It will be an autologous graft.”

For several years now, the team of prof. Agnieszka Dobrzyń from the Nencki Institute of Experimental Biology has been refining the model of transformation of human stem cells towards cells producing insulin and glucagon which will be another milestone in achieving the goal. In August 2018 it was possible to overcome another obstacle, through was the purchase of CELLINK’s specialized 3D bioprinter, which allowed for sterile printing of pancreatic petals. The next stage of the project implementation is to start at the turn of 2018/2019 and it will include preparations for the first animal trials.

True benefits

The benefits of the development of medicine are unquestionable, but how will it look for the average patient? Bionic pancreas is primarily aimed at preventing the development of further complications in patients struggling with diabetes. First, the program would cover people who would potentially be eligible for pancreas transplantation. These are patients who have already had severe complications, so the transplant provides a real guarantee of blocking secondary diabetes complications.

In addition to the priority aspect of saving human lives, the additional benefit of a bionic pancreas could be the reduction of health care expenses. In Poland, these expenses are over 9% total outlays on health care: one-fifth of this sum is for the treatment of diabetes-related complications. Implementation of the project assumptions could significantly reduce both financial outlays for the treatment of patients suffering from complications and the costs of immunosuppressive treatment. Over time, the target group will expand while improving patients’ quality of life.

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Davide Sher

Since 2002, Davide has built up extensive experience as both a technology journalist and communications consultant. Born in Milan, Italy, he spent 12 years in the United States, where he received his undergraduate degree from SUNY Stony Brook. He is a senior analyst for US-based firm SmarTech Publishing focusing on the additive manufacturing industry. He founded London-based 3D Printing Business Media Ltd. (now 3dpbm) which specializes in marketing, editorial and market analysys&consultancy services for the additive manufacturing industry. 3dpbm publishes 3D Printing Business Directory, the largest global directory of companies related to 3DP, as well as several editorial websites, including 3D Printing Media Network and Replicatore.

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